Multiple Dorsoventral Origins of Oligodendrocyte Generation in the Spinal Cord and Hindbrain

@article{Vallstedt2005MultipleDO,
  title={Multiple Dorsoventral Origins of Oligodendrocyte Generation in the Spinal Cord and Hindbrain},
  author={Anna Vallstedt and Joanna M Klos and J. Ericson},
  journal={Neuron},
  year={2005},
  volume={45},
  pages={55-67}
}
Studies have indicated that oligodendrocytes in the spinal cord originate from a ventral progenitor domain defined by expression of the oligodendrocyte-determining bHLH proteins Olig1 and Olig2. Here, we provide evidence that progenitors in the dorsal spinal cord and hindbrain also produce oligodendrocytes and that the specification of these cells may result from a dorsal evasion of BMP signaling over time. Moreover, we show that the generation of ventral oligodendrocytes in the spinal cord… Expand
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