Multiple Domains in Caveolin-1 Control Its Intracellular Traffic

  title={Multiple Domains in Caveolin-1 Control Its Intracellular Traffic},
  author={Thomas Machleidt and W P Li and Pingsheng Liu and Richard G. W. Anderson},
  journal={The Journal of Cell Biology},
  pages={17 - 28}
Caveolin-1 is an integral membrane protein of caveolae that is thought to play an important role in both the traffic of cholesterol to caveolae and modulating the activity of multiple signaling molecules at this site. The molecule is synthesized in the endoplasmic reticulum, transported to the cell surface, and undergoes a poorly understood recycling itinerary. We have used mutagenesis to determine the parts of the molecule that control traffic of caveolin-1 from its site of synthesis to the… CONTINUE READING
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