Multiple Cytokines Are Released When Blood from Patients with Tuberculosis Is Stimulated with Mycobacterium tuberculosis Antigens

@inproceedings{Kellar2011MultipleCA,
  title={Multiple Cytokines Are Released When Blood from Patients with Tuberculosis Is Stimulated with Mycobacterium tuberculosis Antigens},
  author={Kathryn L. Kellar and Jennifer Gehrke and Stephen E. Weis and Aida Mahmutovic-Mayhew and Blachy Davila and Margan J. Zajdowicz and Robin Scarborough and Philip A Lobue and Alfred Lardizabal and Charles L. Daley and Randall R. Reves and J S L Bernardo and Brandon H. Campbell and William C. Whitworth and Gerald H Mazurek},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Mycobacterium tuberculosis (Mtb) infection may cause overt disease or remain latent. Interferon gamma release assays (IGRAs) detect Mtb infection, both latent infection and infection manifesting as overt disease, by measuring whole-blood interferon gamma (IFN-γ) responses to Mtb antigens such as early secreted antigenic target-6 (ESAT-6), culture filtrate protein 10 (CFP-10), and TB7.7. Due to a lack of adequate diagnostic standards for confirming latent Mtb infection, IGRA… CONTINUE READING
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