Multiple Chemical Inducible Tal Effectors for Genome Editing and Transcription Activation.

Abstract

Inducible modulation is often required for precise investigations and manipulations of dynamic biological processes. Transcription activator-like effectors (TALEs) provide a powerful tool for targeted gene editing and transcriptional programming. We designed a series of chemical inducible systems by coupling TALEs with a mutated human estrogen receptor… (More)
DOI: 10.1021/acschembio.7b00606

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