Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?

  title={Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?},
  author={Alexander M. Walter and Alexander J A Groffen and Jakob Balslev S\orensen and Matthijs Verhage},
  journal={Trends in neurosciences},
  volume={34 9},
Regulated neurotransmitter secretion depends on Ca(2+) sensors, C2 domain proteins that associate with phospholipids and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) complexes to trigger release upon Ca(2+) binding. Ca(2+) sensors are thought to prevent spontaneous fusion at rest (clamping) and to promote fusion upon Ca(2+) activation. At least eight, often coexpressed, Ca(2+) sensors have been identified in mammals. Accumulating evidence suggests that multiple… CONTINUE READING