Multiple CD11c+ Cells Collaboratively Express IL-1β To Modulate Stromal Vascular Endothelial Growth Factor and Lymph Node Vascular–Stromal Growth

@article{Benahmed2014MultipleCC,
  title={Multiple CD11c+ Cells Collaboratively Express IL-1$\beta$ To Modulate Stromal Vascular Endothelial Growth Factor and Lymph Node Vascular–Stromal Growth},
  author={F. Benahmed and S. Chyou and Dragos C. Dasoveanu and Jingfeng Chen and Varsha Kumar and Y. Iwakura and T. Lu},
  journal={The Journal of Immunology},
  year={2014},
  volume={192},
  pages={4153 - 4163}
}
Lymphadenopathy in autoimmune and other lymphoproliferative diseases is in part characterized by immunoblasts and vascular proliferation. The lymph node vasculature, along with the nonvascular stromal compartment, supports lymphocyte function, and targeting vascular–stromal expansion in inflamed nodes may modulate lymphocyte function in disease. CD11c+ cells are essential for vascular–stromal proliferation and the upregulation of vascular endothelial growth factor (VEGF) needed for vascular… Expand
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