Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors.

@article{Berro2011MultipleCC,
  title={Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors.},
  author={Reem G Berro and Per Johan Klasse and D. I. Vargas Lascano and Ayanna J. Flegler and Kirsten A. Nagashima and Rogier W. Sanders and Thomas P. Sakmar and Thomas J Hope and John P. Moore},
  journal={Journal of virology},
  year={2011},
  volume={85 16},
  pages={8227-40}
}
Resistance to small-molecule CCR5 inhibitors arises when HIV-1 variants acquire the ability to use inhibitor-bound CCR5 while still recognizing free CCR5. Two isolates, CC101.19 and D1/85.16, became resistant via four substitutions in the gp120 V3 region and three in the gp41 fusion peptide (FP), respectively. The binding characteristics of a panel of monoclonal antibodies (MAbs) imply that several antigenic forms of CCR5 are expressed at different levels on the surfaces of U87-CD4-CCR5 cells… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
18 Citations
60 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection

  • J Garcia-Perez
  • J. Biol
  • 2011
Highly Influential
4 Excerpts

Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition

  • K Maeda
  • J. Mol. Biol
  • 2008
Highly Influential
4 Excerpts

Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor

  • Kuhmann, E S.
  • J. Virol
  • 2004
Highly Influential
4 Excerpts

Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41

  • Anastassopoulou, G C.
  • Virology
  • 2011
1 Excerpt

Similar Papers

Loading similar papers…