Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death

@article{Wang2006MultipleBF,
  title={Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death},
  author={Thomas J. Wang and Philimon N. Gona and Martin G. Larson and Geoffrey H Tofler and Daniel Levy and Christopher Newton-Cheh and Paul F. Jacques and Nader Rifai and Jacob Selhub and Sander J. Robins and Emelia J. Benjamin and Ralph B. D'Agostino and Ramachandran S. Vasan},
  journal={The New England Journal of Medicine},
  year={2006},
  volume={355},
  pages={2631-2639}
}
BACKGROUND: Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events. METHODS: We measured 10 biomarkers in 3209 participants attending a routine examination cycle of the Framingham Heart Study: the levels of C-reactive protein, B-type natriuretic peptide, N-terminal pro-atrial natriuretic peptide, aldosterone, renin, fibrinogen, D-dimer, plasminogen-activator inhibitor type 1, and… 

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