Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death

@article{Wang2006MultipleBF,
  title={Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death},
  author={Thomas J. Wang and Philimon N. Gona and Martin G. Larson and Geoffrey H Tofler and Daniel Levy and Christopher Newton-Cheh and Paul F. Jacques and Nader Rifai and Jacob Selhub and Sander J. Robins and Emelia J. Benjamin and Ralph B. D'Agostino and Ramachandran S. Vasan},
  journal={The New England Journal of Medicine},
  year={2006},
  volume={355},
  pages={2631-2639}
}
BACKGROUND: Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events. METHODS: We measured 10 biomarkers in 3209 participants attending a routine examination cycle of the Framingham Heart Study: the levels of C-reactive protein, B-type natriuretic peptide, N-terminal pro-atrial natriuretic peptide, aldosterone, renin, fibrinogen, D-dimer, plasminogen-activator inhibitor type 1, and… 
View via Publisher
534 Citations
Highly Influential Citations
3
Background Citations
50
Methods Citations
8
Results Citations
6

Figures and Tables from this paper

534 Citations

Citation Type

Citation Type

Circulating biomarkers for long-term cardiovascular risk stratification in apparently healthy individuals from the MONICA 10 cohort
TLDR
H-CRP, suPAR, and particularly NT-proBNP predicted cardiovascular death and may enhance prognostication beyond traditional risk factors in apparently healthy individuals and were significantly associated with significant NRI.
Multiple Biomarkers for Risk Prediction in Chronic Heart Failure
TLDR
In ambulatory chronic heart failure patients, a score derived from multiple biomarkers integrating diverse biological pathways substantially improves prediction of adverse events beyond current metrics.
Prognostic value of multiple biomarkers in American Indians free of clinically overt cardiovascular disease (from the Strong Heart Study).
Novel biomarkers of cardiovascular disease: Applications in clinical practice
TLDR
This review will initially describe the fundamental approach to evaluate a novel biomarker, and discuss novel applications of cardiovascular biomarkers, more specifically prediction of ventricular arrhythmias, and the use of biomarkers in composite risk prediction models.
Role of Cardiac Biomarkers in Epidemiology and Risk Outcomes.
TLDR
Among the various biomarkers, cardiac troponin appears to be the most promising for prediction of future cardiovascular events in a wide variety of patient populations.
Placental growth factor and B-type natriuretic peptide as independent predictors of risk from a multibiomarker panel in suspected acute coronary syndrome (Acute Risk and Related Outcomes Assessed With Cardiac Biomarkers [ARROW]) study.
N-terminal pro-B-type natriuretic peptide is associated with sudden cardiac death risk: the Cardiovascular Health Study.
Protein Biomarkers and Risk of Atrial Fibrillation
TLDR
Investigation of protein biomarkers associated with incident atrial fibrillation may improve the understanding of the pathophysiology, risk prediction, and development of new therapeutics for AF and found decreased levels of IGF1 and increased levelsof IGFBP1 and NT-proBNP were associated with higher risk of incident AF.
Utility of C-reactive protein for cardiovascular risk stratification across three age groups in subjects without existing cardiovascular diseases.
Multimarker Approach to Identify Patients with Coronary Artery Disease at High Risk for Subsequent Cardiac Adverse Events: The Multi-Biomarker Study
TLDR
In conclusion, canonical discriminant analysis of the multimarker approach is able to define the risk threshold at the individual patient level for personalized medicine.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 46 REFERENCES
Comparative Impact of Multiple Biomarkers and N-Terminal Pro-Brain Natriuretic Peptide in the Context of Conventional Risk Factors for the Prediction of Recurrent Cardiovascular Events in the Heart Outcomes Prevention Evaluation (HOPE) Study
TLDR
A model consisting of simple traditional risk factors and Nt-proBNP provided the best clinical prediction in the secondary-prevention population.
Plasma natriuretic peptide levels and the risk of cardiovascular events and death.
TLDR
Peptide levels predicted the risk of death and cardiovascular events after adjustment for traditional risk factors and excess risk was apparent at natriuretic peptide levels well below current thresholds used to diagnose heart failure.
N-terminal pro-brain natriuretic peptide, C-reactive protein, and urinary albumin levels as predictors of mortality and cardiovascular events in older adults.
An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: the atherosclerosis risk in communities study.
TLDR
The findings reinforce the utility of major, modifiable risk factor assessment to identify individuals at risk for CHD for preventive action and suggest that routine measurement of these novel markers is not warranted for risk assessment.
C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease.
TLDR
The long-term stability of C-reactive protein values was similar to that of both blood pressure and total serum cholesterol, and recommendations regarding its use in predicting the likelihood of coronary heart disease may need to be reviewed.
C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study.
TLDR
Elevated CRP level provided no further prognostic information beyond traditional office risk factor assessment to predict future major CVD and major coronary heart disease in this population sample.
Established and emerging plasma biomarkers in the prediction of first atherothrombotic events.
TLDR
Although risk-scoring systems that additionally evaluate traditional risk factors such as smoking, hypertension, and diabetes greatly improve risk prediction, multiple studies demonstrate that 20% to 25% of all future events occur in individuals with only 1 of these factors.
Fibrinolytic activation markers predict myocardial infarction in the elderly. The Cardiovascular Health Study.
TLDR
D-dimer and PAP, but not PAI-1, predicted future myocardial infarction in men and women over age 65, and relationships were independent of other risk factors, including inflammation markers.
Fibrin D-Dimer and Coronary Heart Disease: Prospective Study and Meta-Analysis
TLDR
There may be an association between circulating D-dimer values and CHD, but further studies are needed to determine the extent to which this is causal.
C-Reactive Protein as a Predictor of Cardiovascular Risk in a Population With a High Prevalence of Diabetes: The Strong Heart Study
TLDR
In subgroup analysis, CRP was strongly related to incident CVD among nondiabetic women participants, even after adjustment for traditional CVD risk factors and other indicators of inflammation, andCRP was not predictive of CVD in important subgroups, such as those with diabetes.
...
1
2
3
4
5
...