Multiple Antimicrobial Resistance in Plague: An Emerging Public Health Risk

@article{Welch2007MultipleAR,
  title={Multiple Antimicrobial Resistance in Plague: An Emerging Public Health Risk},
  author={Timothy J Welch and Wolfgang Florian Fricke and Patrick F McDermott and David G. White and M L Rosso and David A. Rasko and Mark K. Mammel and Mark Eppinger and Mary J Rosovitz and David M. Wagner and Lila Rahalison and J Eugene Leclerc and Jeffrey M. Hinshaw and Luther E. Lindler and Thomas A. Cebula and {\'E}lisabeth Carniel and Jacques Ravel},
  journal={PLoS ONE},
  year={2007},
  volume={2}
}
Antimicrobial resistance in Yersinia pestis is rare, yet constitutes a significant international public health and biodefense threat. In 1995, the first multidrug resistant (MDR) isolate of Y. pestis (strain IP275) was identified, and was shown to contain a self-transmissible plasmid (pIP1202) that conferred resistance to many of the antimicrobials recommended for plague treatment and prophylaxis. Comparative analysis of the DNA sequence of Y. pestis plasmid pIP1202 revealed a near identical… Expand
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