Multiple Actions of Pituitary Adenylyl Cyclase Activating Peptide in Nervous System Development and Regeneration

@article{Waschek2002MultipleAO,
  title={Multiple Actions of Pituitary Adenylyl Cyclase Activating Peptide in Nervous System Development and Regeneration},
  author={James A. Waschek},
  journal={Developmental Neuroscience},
  year={2002},
  volume={24},
  pages={14 - 23}
}
  • J. Waschek
  • Published 1 July 2002
  • Biology, Medicine
  • Developmental Neuroscience
Pituitary adenylyl cyclase activating peptide (PACAP) is widely expressed in the embryonic brain at the onset of neurogenesis, and is strongly upregulated in several models of nerve injury. Moreover, high-affinity PACAP receptors are expressed in proliferative zones in the embryonic and postnatal nervous system suggesting that PACAP regulates the development of both neuronal and glial precursors. Tissue culture studies indicate that PACAP exerts a variety of growth factor-like actions that… 
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Pituitary adenylyl cyclase‐activating peptide counteracts hedgehog‐dependent motor neuron production in mouse embryonic stem cell cultures
TLDR
It is demonstrated that PACAP completely blocked Shh‐dependent motor neuron generation from embryonic stem cell cultures and reduced mRNA levels of the Shh target gene Gli‐1 and several ventral spinal cord patterning genes.
Pituitary adenylate cyclase‐activating polypeptide regulates forebrain neural stem cells and neurogenesis in vitro and in vivo
TLDR
It is determined that the intracerebroventricular infusion of PACAP into the adult forebrain was sufficient to increase neurogenesis significantly in both the hippocampus and the subventricular zone and, therefore, may be ideal for promoting the endogenous regeneration of damaged brain tissue.
Pro- and Anti-Mitogenic Actions of Pituitary Adenylate Cyclase-Activating Polypeptide in Developing Cerebral Cortex: Potential Mediation by Developmental Switch of PAC1 Receptor mRNA Isoforms
TLDR
It is found that mice deficient in PACAP exhibited a decrease in the BrdU labeling index (LI) in E9.5 cortex, suggesting that PACAP normally promotes proliferation at this stage, and establishes a novel culture model in which the viability of very early cortical precursors could be maintained.
The Neuropeptide Pituitary Adenylate Cyclase‐Activating Polypeptide Exerts Anti‐Apoptotic and Differentiating Effects during Neurogenesis: Focus on Cerebellar Granule Neurones and Embryonic Stem Cells
TLDR
The anti‐apoptotic and pro‐differentiating effects of PACAP characterised in cerebellar neuroblasts as well as ES and EB cells indicate that PACAP acts not only as a neurohormone and a neurotransmitter, but also as a growth factor.
PACAP promotes sensory neuron differentiation: blockade by neurotrophic factors
Pleiotropic Functions of PACAP in the CNS
TLDR
The results suggest that PACAP itself and PACAP‐stimulated secretion of IL‐6 synergistically inhibit apoptotic cell death in the hippocampus, strongly suggesting thatPACAP plays very important roles in neuroprotection in adult brain as well as astrocyte differentiation during development.
Pituitary Adenylate Cyclase-Activating Polypeptide and Sonic Hedgehog Interact to Control Cerebellar Granule Precursor Cell Proliferation
TLDR
Observations suggest that G-protein-coupled receptors, such as PAC1, serve as sensors of environmental cues, coordinating diverse neurogenetic signals in the developing cerebellum.
Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases
TLDR
The current findings on the neurotrophic and neuroprotective effects of PACAP in different brain injury models, such as cerebral ischemia, Parkinson's disease (PD), and Alzheimer’s disease (AD), are summarized to provide information for the future development of therapeutic strategies in treatment of these neurodegenerative diseases.
Cellular localization of pituitary adenylate cyclase-activating peptide (PACAP) following traumatic brain injury in humans
TLDR
It is hypothesized that the increase of glial PACAP immunoreactivity may be interpreted as part of a complex endogenous neuroprotective response in the pericontusional regions, but the precise role of PACAP following TBI is yet to be determined.
Pituitary adenylate cyclase activating polypeptide and PAC1 receptor signaling increase Homer 1a expression in central and peripheral neurons
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References

SHOWING 1-10 OF 81 REFERENCES
Pituitary adenylate cyclase-activating polypeptide is an autocrine inhibitor of mitosis in cultured cortical precursor cells.
  • N. Lu, E. Dicicco-Bloom
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
It is reported that pituitary adenylate cyclase-activating polypeptide (PACAP), a new member of the vasoactive intestinal peptide family expressed in embryonic brain, promotes this transition from proliferation to differentiation and induces cell cycle withdrawal.
Pituitary Adenylyl Cyclase-Activating Polypeptide Stimulates DNA Synthesis But Delays Maturation of Oligodendrocyte Progenitors
TLDR
The findings indicate that PACAP may act at two stages during OL development to stimulate proliferation and (2) delay maturation and/or myelinogenesis.
Neural tube expression of pituitary adenylate cyclase-activating peptide (PACAP) and receptor: potential role in patterning and neurogenesis.
TLDR
PACAP is thus an early inducer of cAMP levels in the embryo and may act in the neural tube during patterning to control cell proliferation and gene expression.
Neurotrophic and neuroprotective effects of pituitary adenylate cyclase‐activating polypeptide (pACAP) on mesencephalic dopaminergic neurons
TLDR
The results show that PACAP has a neurotrophic action on dopaminergic neurons and partially protects them against 6‐OHDA induced neurotoxicity.
Pituitary adenylate cyclase-activating polypeptide promotes cell survival and neurite outgrowth in rat cerebellar neuroblasts
PACAP Functions as a Neurotrophic Factor a
TLDR
Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from ovine hypothalamic tissues during an attempt to isolate a novel hypophysiotropic hormone based on the ability to activate adenYLate Cyclase in rat pituitary cell cultures.
Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development.
TLDR
Evidence is provided that PACAP can act in vivo as a trophic factor during rat brain development and increases proliferation and/or inhibits programmed cell death of granule cells, as well as stimulating neuronal migration from the external granule cell layer toward the internal granules cell layer.
Autocrine expression and ontogenetic functions of the PACAP ligand/receptor system during sympathetic development.
The superior cervical ganglion (SCG) is a well-characterized model of neural development, in which several regulatory signals have been identified. Vasoactive intestinal peptide (VIP) has been found…
Pituitary adenylate cyclase activating polypeptide prevents apoptosis in cultured cerebellar granule neurons.
TLDR
The activation of type I PACAP receptors may contribute to the survival of cerebellar granule neurons by reducing the development of apoptosis in a dose-dependent manner.
Expression of pituitary adenylate cyclase activating polypeptide (PACAP) in the postnatal and adult rat cerebellar cortex
TLDR
The findings suggest that PACAP could be a neurotransmitter in the adult cerebellum and provide a morphological correlate for the reported in vitro anti-apoptotic PACAP effects on cerebellar granule cells from 1-week-old rats.
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