Multiple‐dose quazepam kinetics

@article{Chung1984MultipledoseQK,
  title={Multiple‐dose quazepam kinetics},
  author={Menger Chung and James M. Hilbert and Richard Gural and Elaine R. Radwanski and Samson Symchowicz and Nicola Zampaglione},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1984},
  volume={35}
}
Quazepam, a benzodiazepine hypnotic, was studied in normal subjects to evaluate steady‐state kinetics of quazepam and of its major active plasma metabolites, 2‐oxoquazepam and N‐desalkyl‐2‐oxoquazepam, after 15 mg once daily by mouth for 14 days. The kinetics of quazepam and 2‐oxoquazepam can be best described by a two‐compartment open model with first‐order absorption/formation kinetics. Quazepam was rapidly absorbed and its two major plasma metabolites appeared very quickly in systemic… 
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