Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation

@article{Zhang2009MultipleTR,
  title={Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation},
  author={Hongjie Zhang and Elizabeth T Ables and Christine F. Pope and M. Kay Washington and Susan B. Hipkens and Anna L. Means and Gunter Path and Jochen Seufert and Robert H. Costa and Andrew B. Leiter and Mark A Magnuson and Maureen Gannon},
  journal={Mechanisms of Development},
  year={2009},
  volume={126},
  pages={958-973}
}
Within the developing pancreas Hepatic Nuclear Factor 6 (HNF6) directly activates the pro-endocrine transcription factor, Ngn3. HNF6 and Ngn3 are each essential for endocrine differentiation and HNF6 is also required for embryonic duct development. Most HNF6(-/-) animals die as neonates, making it difficult to study later aspects of HNF6 function. Here, we describe, using conditional gene inactivation, that HNF6 has specific functions at different developmental stages in different pancreatic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…