Multiple, small dose administration of (-)deprenyl enhances catecholaminergic activity and diminishes serotoninergic activity in the brain and these effects are unrelated to MAO-B inhibition.

J. Knoll; I. Miklya

Corpus ID: 13084296

Multiple, small dose administration of (-)deprenyl enhances catecholaminergic activity and diminishes serotoninergic activity in the brain and these effects are unrelated to MAO-B inhibition.

@article{Knoll1994MultipleSD,
  title={Multiple, small dose administration of (-)deprenyl enhances catecholaminergic activity and diminishes serotoninergic activity in the brain and these effects are unrelated to MAO-B inhibition.},
  author={J. Knoll and I. Miklya},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1994},
  volume={328 1},
  pages={
          1-15
        }
}

J. Knoll, I. Miklya

Published 1994

Biology, Medicine

Archives internationales de pharmacodynamie et de therapie

As a measure of the basic activity of the catecholaminergic and serotoninergic systems, the biogenic amines released from freshly excised brain tissue were measured by means of HPLC with electrochemical detection. Rats of both sexes were injected subcutaneously, daily for 21 days, either with saline or with a dose of one of the enantiomers of the following compounds: deprenyl; p-fluorodeprenyl; 1-phenyl-2-propylaminopentane, a deprenyl analogue free of MAO-B inhibitory potency; methamphetamine… CONTINUE READING

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