Multiplatform molecular profiling identifies potentially targetable biomarkers in malignant phyllodes tumors of the breast.

@article{Gatalica2016MultiplatformMP,
  title={Multiplatform molecular profiling identifies potentially targetable biomarkers in malignant phyllodes tumors of the breast.},
  author={Zoran Gatalica and Semir Vranic and Anatole Ghazalpour and Joanne X. Xiu and Idris Tolgay Ocal and John T. McGill and Ryan P. Bender and Erin Discianno and Aaron Schlum and Souzan Sanati and Juan Pablo Palazzo and Sandeep K. Reddy and Barbara A. Pockaj},
  journal={Oncotarget},
  year={2016},
  volume={7 2},
  pages={
          1707-16
        }
}
Malignant phyllodes tumor is a rare breast malignancy with sarcomatous overgrowth and with limited effective treatment options for recurrent and metastatic cases. Recent clinical trials indicated a potential for anti-angiogenic, anti-EGFR and immunotherapeutic approaches for patients with sarcomas, which led us to investigate these and other targetable pathways in malignant phyllodes tumor of the breast. Thirty-six malignant phyllodes tumors (including 8 metastatic tumors with two cases having… CONTINUE READING

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