• Materials Science, Medicine
  • Published in Nature materials 2004
  • DOI:10.1038/nmat1159

Multiphoton microscopy guides neurotrophin modification with poly(ethylene glycol) to enhance interstitial diffusion

@article{Stroh2004MultiphotonMG,
  title={Multiphoton microscopy guides neurotrophin modification with poly(ethylene glycol) to enhance interstitial diffusion},
  author={Mark Stroh and Warren R. Zipfel and Rebecca Marie Williams and Shu Chin Ma and Watt W. Webb and W. Mark Saltzman},
  journal={Nature Materials},
  year={2004},
  volume={3},
  pages={489-494}
}
Brain-derived neurotrophic factor (BDNF) is a promising therapeutic agent for the treatment of neurodegenerative diseases. However, the limited distribution of this molecule after administration into the brain tissue considerably hampers its efficacy. Here, we show how multiphoton microscopy of fluorescently tagged BDNF in brain-tissue slices provides a useful and rapid screening method for examining the diffusion of large molecules in tissues, and for studying the effects of chemical… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Temporary Neurotrophin Treatment Prevents Deafness-Induced Auditory Nerve Degeneration and Preserves Function.

VIEW 2 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED