Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo.

  title={Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo.},
  author={Scott B. Raymond and Jesse Skoch and Kullervo Hynynen and Brian J. Bacskai},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={27 2},
Ultrasound (US) enhanced with microbubble contrast agents may transiently disrupt the blood-brain barrier (BBB) with minimal damage, providing a technique for noninvasive, localized drug-delivery deep within the brain. The mechanism and temporal profile of disruption are not understood, owing to the limitations of imaging modalities used previously. In this study, we monitored US-induced BBB disruption with multiphoton microscopy, providing high-resolution temporal and spatial information about… CONTINUE READING


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