Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo

  title={Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo},
  author={Michael O Breckwoldt and Franz Michael Josef Pfister and Peter M. J Bradley and Petar Marinkovi{\'c} and Philip R Williams and Monika S. Brill and Barbara Plomer and Anja Schmalz and Daret K. St. Clair and Ronald Naumann and Oliver Griesbeck and Markus Schwarzl{\"a}nder and Leanne Godinho and Florence Martine Bareyre and Tobias P Dick and Martin Kerschensteiner and Thomas Misgeld},
  journal={Nature Medicine},
Mitochondrial redox signals have a central role in neuronal physiology and disease. Here we describe a new optical approach to measure fast redox signals with single-organelle resolution in living mice that express genetically encoded redox biosensors in their neuronal mitochondria. Moreover, we demonstrate how parallel measurements with several biosensors can integrate these redox signals into a comprehensive characterization of mitochondrial function. This approach revealed that axonal… CONTINUE READING
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