Multiparametric molecular imaging provides mechanistic insights into sympathetic innervation impairment in the viable infarct border zone.

@article{Lautamaki2015MultiparametricMI,
  title={Multiparametric molecular imaging provides mechanistic insights into sympathetic innervation impairment in the viable infarct border zone.},
  author={Riikka Lautamaki and Tetsuo Sasano and Takahiro Higuchi and Stephan G. Nekolla and Albert C. Lardo and Daniel P. Holt and Robert F. Dannals and M. Roselle Abraham and Frank M. Bengel},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2015},
  volume={56 3},
  pages={
          457-63
        }
}
UNLABELLED Impaired catecholamine handling in the viable infarct border zone may play an important role in ventricular remodeling and lethal arrhythmia. We sought to get further biologic insights into cardiac sympathetic neuronal pathology after myocardial infarction, using multiple tomographic imaging techniques. METHODS In a porcine model of myocardial infarction (n = 13), PET and MR imaging were performed after 4-6 wk and integrated with electrophysiologic testing and postmortem histology… CONTINUE READING
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