Multiparametric evaluation of the toxic responses of normal human cells treated in vitro with different classes of environmental toxicants.

@article{Allred1982MultiparametricEO,
  title={Multiparametric evaluation of the toxic responses of normal human cells treated in vitro with different classes of environmental toxicants.},
  author={Lawrence E. Allred and James W. Oldham and George E. Milo and O R Kindig and Charles C. Capen},
  journal={Journal of toxicology and environmental health},
  year={1982},
  volume={10 1},
  pages={
          143-56
        }
}
Eight compounds representing three classes of chemicals were evaluated for their toxic effects on normal neonatal human foreskin fibroblasts in vitro. A battery of toxicity assays was employed to measure the effects of the chemicals on cell viability, DNA synthesis, protein synthesis, DNA repair synthesis, cell ultrastructure, membrane-bound and soluble cytoplasmic proteins, and the activities of six enzymes: beta-glucuronidase, acid phosphatase, gamma-glutamyl transpeptidase, alkaline… 
4 Citations
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A conundrum in molecular toxicology: Molecular and biological changes during neoplastic transformation of human cells
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Historically, this work has assumed only a limited role for epigenetic modulation of molecular changes that occur during progression; however, the data suggest quite strongly that nonmalignant tumor populations can be converted to a more malignant phenotype without additional mutations taking place and, conversely, malignant populationsCan be downregulated to a nontumorigenic phenotype.
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