Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown

@inproceedings{WinogradKatz2009MultiparametricAO,
  title={Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown},
  author={Sabina Winograd-Katz and Shalev Itzkovitz and Zvi Kam and Benjamin Geiger},
  booktitle={The Journal of cell biology},
  year={2009}
}
Cell adhesion to the extracellular matrix is mediated by elaborate networks of multiprotein complexes consisting of adhesion receptors, cytoskeletal components, signaling molecules, and diverse adaptor proteins. To explore how specific molecular pathways function in the assembly of focal adhesions (FAs), we performed a high-throughput, high-resolution, microscopy-based screen. We used small interfering RNAs (siRNAs) to target human kinases, phosphatases, and migration- and adhesion-related… CONTINUE READING

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