Multiparameter mechanical and morphometric screening of cells

Abstract

We introduce a label-free method to rapidly phenotype and classify cells purely based on physical properties. We extract 15 biophysical parameters from cells as they deform in a microfluidic stretching flow field via high-speed microscopy and apply machine-learning approaches to discriminate different cell types and states. When employing the full 15… (More)
DOI: 10.1038/srep37863

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