Multiparameter In Vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using iPSC Cells

  title={Multiparameter In Vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using iPSC Cells},
  author={Oksana Sirenko and Carole Crittenden and Nick Callamaras and Jayne Hesley and Yen-Wen Chen and Carlos Funes and Ivan Rusyn and Blake D. Anson and Evan F. Cromwell},
  journal={Journal of Biomolecular Screening},
  pages={39 - 53}
A large percentage of drugs fail in clinical studies due to cardiac toxicity; thus, development of sensitive in vitro assays that can evaluate potential adverse effects on cardiomyocytes is extremely important for drug development. Human cardiomyocytes derived from stem cell sources offer more clinically relevant cell-based models than those presently available. Human-induced pluripotent stem cell–derived cardiomyocytes are especially attractive because they express ion channels and demonstrate… 

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