Multinucleate cell angiohistiocytoma: report of two cases with no evidence of human herpesvirus-8 infection.

@article{Sass2000MultinucleateCA,
  title={Multinucleate cell angiohistiocytoma: report of two cases with no evidence of human herpesvirus-8 infection.},
  author={Ursula Sass and Joseph Christian Gruba Noel and J. Andr{\'e} and Thierry Simonart},
  journal={Journal of cutaneous pathology},
  year={2000},
  volume={27 5},
  pages={
          258-61
        }
}
Multinucleate cell angiohistiocytoma (MCA) is a vascular tumor of unknown pathogenesis. Possible misinterpretation of this disorder with Kaposi's sarcoma (KS), a human herpesvirus-8 (HHV-8)-associated tumor, prompted us to look for this virus in two women with MCA. None of the multiple skin specimens obtained from both our patients produced amplified HHV-8 DNA. Using a cell culture methodology similar to that used for KS, we established cell cultures from MCA lesions. While KS spindle cells are… CONTINUE READING
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