Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin.

@article{GhamariLangroudi2011MultinodalRO,
  title={Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin.},
  author={Masoud Ghamari-Langroudi and Dollada Srisai and Roger D Cone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 1},
  pages={355-60}
}
Melanocortin-4 receptor (MC4R) is critical for energy homeostasis, and the paraventricular nucleus of the hypothalamus (PVN) is a key site of MC4R action. Most studies suggest that leptin regulates PVN neurons indirectly, by binding to receptors in the arcuate nucleus or ventromedial hypothalamus and regulating release of products like α-melanocyte-stimulating hormone (α-MSH), neuropeptide Y (NPY), glutamate, and GABA from first-order neurons onto the MC4R PVN cells. Here, we investigate… CONTINUE READING

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