Multimodal tract-based analysis in ALS patients at 7T: a specific white matter profile?

@article{Verstraete2014MultimodalTA,
  title={Multimodal tract-based analysis in ALS patients at 7T: a specific white matter profile?},
  author={Esther Verstraete and Daniel Louis Polders and Ren{\'e} C. W. Mandl and Martijn M. H. P. van den Heuvel and Jan Herman Veldink and Peter R Luijten and Leonard H van den Berg and Johannes M. Hoogduin},
  journal={Amyotrophic lateral sclerosis & frontotemporal degeneration},
  year={2014},
  volume={15 1-2},
  pages={
          84-92
        }
}
Our objective was to explore the value of additional MR contrasts in elucidating the decrease in fractional anisotropy (FA) as has been observed in the corticospinal tracts (CST) of patients with amyotrophic lateral sclerosis (ALS). Eleven patients and nine healthy control subjects were scanned at 3T and 7T MRI. Whole brain and tract specific comparison was performed of both diffusion weighted (3T), quantitative T1 (qT1), magnetization transfer ratio (MTR) and amide proton transfer weighted… CONTINUE READING

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