Multimodal neurophysiological study of SCA2 and SCA3 autosomal dominant hereditary spinocerebellar ataxias.

BACKGROUND The spinocerebellar ataxias (SCA) are a group of genetic neurodegenerative diseases, clinically and pathologically heterogeneous, characterized by slowly progressive cerebellar ataxia. OBJECTIVE To identify the neural pathways affected neurophysiologically, correlate the findings with the size of CAG expansion and determine the contribution of… CONTINUE READING