Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.


Integrase (IN) is required for lentivirus replication and is a proven drug target for the prevention of AIDS in HIV-1-infected patients. While clinical strand transfer inhibitors disarm the IN active site, allosteric inhibition of enzyme activity through the disruption of IN-IN protein interfaces holds great therapeutic potential. A promising class of… (More)
DOI: 10.1017/erm.2013.15

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