Multimodal fMRI Resting-State Functional Connectivity in Granulin Mutations: The Case of Fronto-Parietal Dementia

@inproceedings{Premi2014MultimodalFR,
  title={Multimodal fMRI Resting-State Functional Connectivity in Granulin Mutations: The Case of Fronto-Parietal Dementia},
  author={Enrico Premi and Franco Cauda and Roberto Gasparotti and Matteo Diano and Silvana Archetti and Alessandro Padovani and Barbara Borroni},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Monogenic dementias represent a great opportunity to trace disease progression from preclinical to symptomatic stages. Frontotemporal Dementia related to Granulin (GRN) mutations presents a specific framework of brain damage, involving fronto-temporal regions and long inter-hemispheric white matter bundles. Multimodal resting-state functional MRI (rs-fMRI) is a promising tool to carefully describe disease signature from the earliest disease phase. OBJECTIVE To define local… CONTINUE READING

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