Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity

  title={Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity},
  author={B. H. Natelson and Xiangling Mao and Aaron J. Stegner and Gudrun Lange and Diana Vu and Michelle Blate and G Kang and Eli Soto and Tolga Kapusuz and Dikoma C. Shungu},
  journal={Journal of the Neurological Sciences},
The purpose of this study was to investigate whether CFS patients without comorbid psychiatric diagnoses differ from CFS patients with comorbid psychiatric diagnoses and healthy control subjects in neuropsychological performance, the proportion with elevated spinal fluid protein or white cell counts, cerebral blood flow (CBF), brain ventricular lactate and cortical glutathione (GSH). The results of the study did not show any differences in any of the outcome measures between CFS patients with… Expand
Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy
The extended MRS analysis of ME/CFS by capturing multi-voxel information across the entire brain may indicate that ME/ CFS involves neuroinflammation. Expand
The effect of comorbid medical and psychiatric diagnoses on chronic fatigue syndrome
It is shown that the presence of co-existing psychiatric diagnoses does not impact on any aspect of the phenomenology of medically unexplained fatigue also known as chronic fatigue syndrome, and psychiatric status is not an important causal contributor to CFS. Expand
Neuroimaging characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review
The frequent observation of additional brain area recruitment and consistent observation of sluggish fMRI signal response suggest abnormal neurovascular coupling in ME/CFS. Expand
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?
The objective is to review the evidence in neuroimaging and dysautonomia evaluation in order to support the neurological involvement and to find biomarkers serving to identify and/or monitor the pathology. Expand
Chronic Fatigue Syndrome and Fibromyalgia
This chapter will review studies on sleep in CFS and FM patients in order to better understand theirSleep problems, effects of treatment of their sleep problems, and differences between these two conditions. Expand
Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome.
It is proposed that the persistence of ME/CFS may involve changes in the regulatory interactions across these physiological axes, and the robustness of this new pathogenic equilibrium may at least in part explain the limited success of conventional single-target therapies. Expand
Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome
It is speculated that the pathogenesis of post-COVID-19 syndrome in some people may be similar to that of ME/CFS, and proposed molecular mechanisms that might explain the fatigue and related symptoms in both illnesses are proposed. Expand
The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review
There is considerable evidence that prior outbreaks of ME/CFS were caused by one or more enterovirus groups, and the methods used in prior studies were inadequate to rule out the presence of chronic enteroviral infections in individuals with ME/ CFS. Expand


Spinal Fluid Abnormalities in Patients with Chronic Fatigue Syndrome
The results support two hypotheses: that some CFS patients have a neurological abnormality that may contribute to the clinical picture of the illness and that immune dysregulation within the central nervous system may be involved in this process. Expand
Brain MRI abnormalities exist in a subset of patients with chronic fatigue syndrome
The C FS-No Psych group showed a significantly larger number of brain abnormalities on T2 weighted images than the CFS-Psych and HC groups, which could explain the more severe cognitive impairment previously reported in this subset of CFS patients. Expand
Elevations of ventricular lactate levels occur in both chronic fatigue syndrome and fibromyalgia
While patients with CFS, FM and comorbid CFS and FM can be differentiated from healthy subjects based on measures of CFS lactate, this neuroimaging outcome measure is not a viable biomarker for differentiating CFS from FM or from patients in whom symptoms of the two disorders overlap. Expand
Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology
A pathophysiological model of CFS is investigated in which increased oxidative stress may play a key role in CFS etiopathophysiology, and levels of ventricular lactate and cortical GSH were inversely correlated, and significantly associated with several key indices of physical health and disability. Expand
Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder
Comparing ventricular lactate levels in a new cohort of 17 CFS subjects with those in 19 healthy volunteers and in 21 subjects with major depressive disorder, which is a neuropsychiatric disorder that has significant symptom overlap with CFS found a significant correlation between ventricular CSF lactate and severity of mental fatigue that was specific to the CFS group. Expand
Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T 1H MRS imaging study
CFS is associated with significantly raised concentrations of ventricular lactate, potentially consistent with recent evidence of decreased cortical blood flow, secondary mitochondrial dysfunction, and/or oxidative stress abnormalities in the disorder. Expand
A twin study of cognitive function in chronic fatigue syndrome: the effects of sudden illness onset.
The researchers conducted a co-twin control study of 22 pairs of monozygotic twins, finding that twin groups had similar intellectual and visual memory functioning, but fatigued twins exhibited decreases in motor functions, speed of information processing, verbal memory, and executive functioning. Expand
Patients with chronic fatigue syndrome have reduced absolute cortical blood flow
The data indicate that patients with CFS have reduced absolute cortical blood flow in rather broad areas when compared with data from healthy controls and that those devoid of psychopathology had the most reductions in cortical flow. Expand
Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease.
Impaired cognition in chronic fatigue syndrome cannot be explained solely by the presence of a psychiatric condition. Expand
Psychiatric morbidity in the chronic fatigue syndrome: are patients with personality disorder more physically impaired?
Compared the functional status of three CFS groups, psychiatric illness and personality disorder was prevalent but neither could explain the effects of CFS on physical functioning and disability. Expand