Multimodal Delivery of Isogenic Mesenchymal Stem Cells Yields Synergistic Protection From Retinal Degeneration and Vision Loss.

@article{Bakondi2016MultimodalDO,
  title={Multimodal Delivery of Isogenic Mesenchymal Stem Cells Yields Synergistic Protection From Retinal Degeneration and Vision Loss.},
  author={Benjamin Bakondi and Sergey Girman and Bin Lu and Shaomei Wang},
  journal={Stem cells translational medicine},
  year={2016}
}
: We previously demonstrated that subretinal injection (SRI) of isogenic mesenchymal stem cells (MSCs) reduced the severity of retinal degeneration in Royal College of Surgeons rats in a focal manner. In contrast, intravenous MSC infusion (MSCIV) produced panoptic retinal rescue. By combining these treatments, we now show that MSCIV supplementation potentiates the MSCSRI-mediated rescue of photoreceptors and visual function. Electrophysiological recording from superior colliculi revealed 3.9… CONTINUE READING