Multimers of anionic amphiphiles mimic calmodulin stimulation of cyclic nucleotide phosphodiesterase.

@article{Gietzen1982MultimersOA,
  title={Multimers of anionic amphiphiles mimic calmodulin stimulation of cyclic nucleotide phosphodiesterase.},
  author={Kimberly Gietzen and Yan Xue and H. J. Galla and H. D. Bader},
  journal={The Biochemical journal},
  year={1982},
  volume={207 3},
  pages={637-40}
}
Oleic acid, phosphatidylserine and pyrenedecanoic acid were found to activate calmodulin-deficient cyclic nucleotide phosphodiesterase at concentrations above their critical micellar concentration. In contrast with calmodulin these activators do not require the presence of Ca2+ for their action. It is shown that the size of phosphatidylserine vesicles is of crucial importance with respect to the activating potency of phosphatidylserine. Fluorescence measurements with the probe pyrenedecanoic… CONTINUE READING