Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus.

@article{White2008MultimerizationOS,
  title={Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus.},
  author={Mitchell R. White and Paul Kingma and Tesfaldet Tecle and Nilgun Kacak and Bruce Linders and John M Heuser and Erika Crouch and Kevan L Hartshorn},
  journal={Journal of immunology},
  year={2008},
  volume={181 11},
  pages={7936-43}
}
Surfactant protein D (SP-D) plays important roles in the initial innate defense against influenza A virus (IAV). The collagen domain of SP-D is probably critical for its homeostatic functions in vivo and has been implicated in the modulation of macrophage responses to SP-D-ligand complexes. For the current studies, we used a panel of rat SP-D mutants lacking all or part of the collagen domain to more specifically evaluate the contributions of this domain to viral interactions. SP-D multimers… CONTINUE READING