Multimeric small interfering ribonucleic acid for highly efficient sequence-specific gene silencing.


Small interfering RNA (siRNA) with 19-21 base pairs has been recently recognized as a new therapeutic agent for effectively silencing a specific gene on a post-transcription level. For siRNA therapeutics, safe and efficient delivery issues are significant hurdles to clinical applications. Here we present a new class of biologically active siRNA structure… (More)
DOI: 10.1038/nmat2626

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