Multimarker approach for the prediction of heart failure incidence in the community.

  title={Multimarker approach for the prediction of heart failure incidence in the community.},
  author={Raghava S Velagaleti and Philimon Nyakauru Gona and Martin G. Larson and Thomas J. Wang and Daniel L{\'e}vy and Emelia J Benjamin and Jacob S Selhub and Paul F Jacques and James B. Meigs and Geoffrey H. Tofler and Ramachandran S. Vasan},
  volume={122 17},
BACKGROUND Several biological pathways are activated in ventricular remodeling and in overt heart failure (HF). There are no data, however, on the incremental utility of a parsimonious set of biomarkers (reflecting pathways implicated in HF) for predicting HF risk in the community. METHODS AND RESULTS We related a multibiomarker panel to the incidence of a first HF event in 2754 Framingham Heart Study participants (mean age, 58 years; 54 women) who were free of HF and underwent routine assays… CONTINUE READING


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