Multilocus parasite gene polymorphism and/or parasite-selected mutations in host genome may discriminate between relapse and reinfection in the failure of miltefosine treatment in visceral leishmaniasis.

Abstract

TO THE EDITOR—In their comprehensive cohort study, Rijal and colleagues have explored the occurrence of failure in miltefosine treatment in 120 visceral leishmaniasis (VL) patients in Nepal; they observed an initial cure rate of 95.8% with an alarming relapse rate of 10.8% and 20.0% at 6 and 12 months, respectively [1]. Similar studies in India have… (More)
DOI: 10.1093/cid/cit506

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