Multilocus interactions at maternal tumor necrosis factor-alpha, tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American women.

@article{Menon2006MultilocusIA,
  title={Multilocus interactions at maternal tumor necrosis factor-alpha, tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American women.},
  author={Ram Menon and Digna R. Velez and Hyagriv N Simhan and Kelli K. Ryckman and Lan Jiang and Poul Thorsen and Ida Vogel and Bo Jacobsson and Mario Merialdi and Scott M. Williams and Stephen J. Fortunato},
  journal={American journal of obstetrics and gynecology},
  year={2006},
  volume={194 6},
  pages={
          1616-24
        }
}
OBJECTIVE We hypothesize that genetic variations (single nucleotide polymorphisms-SNPs) in the tumor necrosis factor-alpha (TNF-alpha), TNF receptors (TNFRI and TNFRII), interleukin-6 (IL-6) and IL-6 receptor (IL-6R) genes predict high-risk status for spontaneous preterm birth (sPTB) in European-American women. In this study we examine the allelic and genotypic variations and the gene-gene interactions in the TNF-alpha, TNFRs, IL-6, and IL-6R genes in maternal DNA samples by using a case… CONTINUE READING
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