Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study.

@article{Motsinger2006MultilocusGI,
  title={Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study.},
  author={Alison A. Motsinger and Marylyn DeRiggi Ritchie and Robert W. Shafer and Gregory K. Robbins and Gene D. Morse and Line Labb{\'e} and Grant R. Wilkinson and David B. Clifford and R. T. D'Aquila and Victoria Anne Johnson and Richard B. Pollard and Thomas C. Merigan and Martin S. Hirsch and John P. Donahue and Richard B Kim and David W. Haas},
  journal={Pharmacogenetics and genomics},
  year={2006},
  volume={16 11},
  pages={837-45}
}
OBJECTIVE For the HIV-1 reverse transcriptase inhibitor efavirenz, variant drug transporter gene ABCB1 may predict virologic response but not plasma efavirenz exposure. Conversely, variant drug metabolizing enzyme gene CYP2B6 predicts greater plasma efavirenz exposure but not virologic response. We examined whether long-term responses to efavirenz, and/or plasma efavirenz exposure, are better predicted by multilocus genetic interactions than by individual polymorphisms. MATERIALS AND METHODS… CONTINUE READING

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