Multilocus Sequence Typing (MLST) for Lineage Assignment and High Resolution Diversity Studies in Trypanosoma cruzi

@inproceedings{Yeo2011MultilocusST,
  title={Multilocus Sequence Typing (MLST) for Lineage Assignment and High Resolution Diversity Studies in Trypanosoma cruzi},
  author={Matthew Yeo and Isabel L. Mauricio and Louisa Alexandra Messenger and Michael David Lewis and Martin Stephen Llewellyn and N. Sebasti{\'a}n Acosta and Tapan Bhattacharyya and Patricio Diosque and Hern{\'a}n Jos{\'e} Carrasco and Michael Alexander Miles},
  booktitle={PLoS neglected tropical diseases},
  year={2011}
}
BACKGROUND Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable genetic and ecological diversity. A standardised MLST protocol that is suitable for assignment of T. cruzi isolates to genetic lineage and for higher resolution diversity studies has not been developed. METHODOLOGY/PRINCIPAL FINDINGS We have… CONTINUE READING