Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1).

@article{Falini2010MultilineageDH,
  title={Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1).},
  author={Brunangelo Falini and Katja Macijewski and Tamara Weiss and Ulrike Bacher and Susanne Schnittger and Wolfgang Kern and Alexander Kohlmann and Hans-Ulrich Klein and Marco Vignetti and Alfonso Piciocchi and Paola Fazi and Maria Paola Martelli and Antonella Vitale and Stefano A Pileri and Miriam Miesner and Antonella Santucci and Claudia Haferlach and Franco Mandelli and Torsten Haferlach},
  journal={Blood},
  year={2010},
  volume={115 18},
  pages={3776-86}
}
NPM1-mutated acute myeloid leukemia (AML) is a provisional entity in the 2008 World Health Organization (WHO) classification of myeloid neoplasms. The significance of multilineage dysplasia (MLD) in NPM1-mutated AML is unclear. Thus, in the 2008 WHO classification, NPM1-mutated AML with MLD is classified as AML with myelodysplasia (MD)-related changes (MRCs). We evaluated morphologically 318 NPM1-mutated AML patients and found MLD in 23.3%. Except for a male predominance and a lower fms-related… CONTINUE READING
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