Multilineage cell involvement in Ph1-negative, bcr-negative chronic myeloid leukemia.

@article{Callea1988MultilineageCI,
  title={Multilineage cell involvement in Ph1-negative, bcr-negative chronic myeloid leukemia.},
  author={Vincenzo Callea and Fausto Morabito and Patrizia Lista and Luigi Pegoraro and Giovanna Rege Cambrin and Angelo Guerrasio and Giuseppe Saglio and Alberto F. Tassinari and Mar{\'i}a T Fierro and Pasquale Iacopino},
  journal={Leukemia research},
  year={1988},
  volume={12 8},
  pages={637-45}
}
We report a case of Ph1-negative, bcr-negative CML-BC, in which the primary leukemic cells displayed T-related antigens (CD7, CD4) in addition to HLA-DR and CD25 determinants. No B-lymphoid, myeloid and megakaryoblastic surface antigens were detected. In spite of this phenotype, DNA analysis revealed a germ-line configuration of the T-cell receptor beta… CONTINUE READING