Multilevel models improve precision and speed of IC50 estimates.

Abstract

AIM Experimental variation in dose-response data of drugs tested on cell lines result in inaccuracies in the estimate of a key drug sensitivity characteristic: the IC50. We aim to improve the precision of the half-limiting dose (IC50) estimates by simultaneously employing all dose-responses across all cell lines and drugs, rather than using a single drug… (More)
DOI: 10.2217/pgs.16.15

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