Multilevel examination of minor salivary gland biopsy for Sjögren's syndrome significantly improves diagnostic performance of AECG classification criteria

@article{Morbini2005MultilevelEO,
  title={Multilevel examination of minor salivary gland biopsy for Sj{\"o}gren's syndrome significantly improves diagnostic performance of AECG classification criteria},
  author={Patrizia Morbini and Antonio Manzo and Roberto Caporali and Oscar Massimiliano Epis and Chiara Villa and Carmine Tinelli and Enrico Solcia and Carlomaurizio Montecucco},
  journal={Arthritis Research & Therapy},
  year={2005},
  volume={7},
  pages={R343 - R348}
}
The recently observed low reproducibility of focus score (FS) assessment at different section depths in a series of single minor salivary gland biopsies highlighted the need for a standardized protocol of extensive histopathological examination of such biopsies in Sjogren's syndrome. For this purpose, a cumulative focus score (cFS) was evaluated on three slides cut at 200-mum intervals from each of a series of 120 salivary biopsies. The cFS was substituted for the baseline FS in the American… CONTINUE READING

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