Multilevel Computational Modeling and Quantitative Analysis of Bone Remodeling

  title={Multilevel Computational Modeling and Quantitative Analysis of Bone Remodeling},
  author={Nicola Paoletti and Pietro Li{\`o} and Emanuela Merelli and Marco Viceconti},
  journal={IEEE/ACM Transactions on Computational Biology and Bioinformatics},
Our work focuses on bone remodeling with a multiscale breadth that ranges from modeling intracellular and intercellular RANK/RANKL signaling to tissue dynamics, by developing a multilevel modeling framework. Several important findings provide clear evidences of the multiscale properties of bone formation and of the links between RANK/RANKL and bone density in healthy and disease conditions. Recent studies indicate that the circulating levels of OPG and RANKL are inversely related to bone… CONTINUE READING
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