Multilayered thin films that sustain the release of functional DNA under physiological conditions.

@article{Zhang2004MultilayeredTF,
  title={Multilayered thin films that sustain the release of functional DNA under physiological conditions.},
  author={Jingtao Zhang and Lynn Chua and David M Lynn},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2004},
  volume={20 19},
  pages={8015-21}
}
The development of thin films and coatings that control the release of DNA from the surfaces of materials could have a significant impact on localized approaches to gene therapy. Here, we report multilayered polyelectrolyte assemblies that sustain the release of functional plasmid DNA from the surfaces of model substrates under physiological conditions. Multilayered assemblies consisting of alternating layers of plasmid DNA encoding for enhanced green fluorescent protein (EGFP) and a synthetic… CONTINUE READING

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