Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures.

Abstract

Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells. The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture. 
DOI: 10.1002/adhm.201500258

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Cite this paper

@article{Engel2015MultilayeredHA, title={Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures.}, author={Brian J. Engel and Pamela E. Constantinou and Lindsey K Sablatura and Nathaniel J Doty and Daniel D. Carson and Mary C. Farach-Carson and Daniel A. Harrington and Thomas I. Zarembinski}, journal={Advanced healthcare materials}, year={2015}, volume={4 11}, pages={1664-74} }