Multilayer Coating of Tetrandrine-loaded PLGA nanoparticles: Effect of surface charges on cellular uptake rate and drug release profile

  title={Multilayer Coating of Tetrandrine-loaded PLGA nanoparticles: Effect of surface charges on cellular uptake rate and drug release profile},
  author={Rui Meng and Ke Wen K. Li and Zhe Chen and Chen Shi},
  journal={Journal of Huazhong University of Science and Technology [Medical Sciences]},
  • R. MengK. Li Chen Shi
  • Published 3 February 2016
  • Materials Science, Chemistry, Biology
  • Journal of Huazhong University of Science and Technology [Medical Sciences]
SummaryThe effect of surface charges on the cellular uptake rate and drug release profile of tetran-drine-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (TPNs) was studied. Stabilizer-free nanoprecipitation method was used in this study for the synthesis of TPNs. A typical layer-by-layer approach was applied for multi-coating particles’ surface with use of poly(styrene sulfonate) sodium salt (PSS) as anionic layer and poly(allylamine hydrochloride) (PAH) as cationic layer. The… 

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