Multihormonal regulation of progesterone synthesis in cultured human midluteal cells.

@article{Devoto1995MultihormonalRO,
  title={Multihormonal regulation of progesterone synthesis in cultured human midluteal cells.},
  author={Luigi Devoto and P. R. Kohen and Olga Castro and Margarita Vega and Jos{\'e} L. Troncoso and Eduardo Hern{\'a}n Charreau},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 5},
  pages={1566-70}
}
The objectives of this investigation were to examine in vivo insulin like-growth factor-I (IGF-I) secretion by the human midcorpora lutea (mid-CL) and the effects of IGF-I, hCG, FSH, and human GH on progesterone (P) production by CL cells obtained from patients at laparotomy. We first examined whether the CL produces IGF-I by measuring IGF-I levels in the ovarian vein from the ovary bearing the CL. The IGF-I concentration in the ovarian vein bearing the CL (206 +/- 31 ng/mL) was significantly… CONTINUE READING