Multigranular exocytosis of Weibel-Palade bodies in vascular endothelial cells.

@article{Valentijn2010MultigranularEO,
  title={Multigranular exocytosis of Weibel-Palade bodies in vascular endothelial cells.},
  author={Karine M. Valentijn and Linda F van Driel and Marjon J Mourik and Gert-Jan Hendriks and Tom J. H. Arends and Abraham J Koster and Jack A. Valentijn},
  journal={Blood},
  year={2010},
  volume={116 10},
  pages={1807-16}
}
Regulated exocytosis of Weibel-Palade bodies (WPBs) is a pivotal mechanism via which vascular endothelial cells initiate repair in response to injury and inflammation. Several pathways have been proposed to enable differential release of bioactive molecules from WPBs under different pathophysiologic conditions. Due to the complexity, many aspects of WPB biogenesis and exocytosis are still poorly understood. Herein, we have investigated the regulated exocytosis of the major WPB constituent, von… CONTINUE READING

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