Multifwnctional Control by Amino Acids of Deprivation-induced Proteolysis in Liver

The control of intracellular proteolysis by amino acids was investigated in rat livers perfused in the single pass mode with various mixtures at multiples of normal plasma concentrations. Twelve amino acids together exhibited no suppressive activity while the remainder (Leu, Phe, Tyr, Gln, Pro, His, Trp, and Met) were inhibitory. Because (a) the effects of… (More)