Multifunctional theranostic Pluronic mixed micelles improve targeted photoactivity of Verteporfin in cancer cells.

@article{Pellosi2017MultifunctionalTP,
  title={Multifunctional theranostic Pluronic mixed micelles improve targeted photoactivity of Verteporfin in cancer cells.},
  author={Diogo Silva Pellosi and Italo Rodrigo Calori and Leonardo Barcelos de Paula and Noboru Hioka and Fabiana Quaglia and Ant{\^o}nio Cl{\'a}udio Tedesco},
  journal={Materials science & engineering. C, Materials for biological applications},
  year={2017},
  volume={71},
  pages={1-9}
}
Nanotechnology development provides new strategies to treat cancer by integration of different treatment modalities in a single multifunctional nanoparticle. In this scenario, we applied the multifunctional Pluronic P123/F127 mixed micelles for Verteporfin-mediated photodynamic therapy in PC3 and MCF-7 cancer cells. Micelles functionalization aimed the targeted delivery by the insertion of biotin moiety on micelle surface and fluorescence image-based through rhodamine-B dye conjugation in the… CONTINUE READING